November 2024: The first human clinical series utilizing dynamic craniotomy with NuCrani plates. The findings underscore the superiority of this innovative approach over traditional fixed plate craniotomy in enhancing patient outcomes and recovery.

The study reveals promising results for the use of dynamic craniotomy, employing reversibly expandable bone flap fixation plates, in the management of traumatic brain injury (TBI). The study explores the advantages of dynamic craniotomy over traditional fixed plate craniotomy, specifically in the treatment of patients with mass lesions such as subdural, epidural, and cerebral hematomas.

Dynamic craniotomy, unlike fixed plate craniotomy, allows for controlled outward movement of the bone flap after surgery to accommodate postoperative cerebral swelling and/or hemorrhage, a common concern in TBI patients. This innovative approach provides a dynamic solution to intracranial volume expansion, reducing the need for repeat surgeries and minimizing complications such as wound healing issues and reoperation. The study evaluated 25 consecutive adult patients who underwent dynamic craniotomy using NuCrani reversibly expandable bone flap fixation plates and related the following findings:

• 84% demonstrated postoperative swelling accommodated by bone flap movement

• No reoperations required

• Bone flaps returned toward normal position after swelling resolved

These findings suggest dynamic cranial fixation may represent a new approach for managing postoperative intracranial swelling.

Krafft, Paul R. MD; Tafel, Ian MD; Khanna, Anjali; Han, Patrick MD; Khanna, Rohit MD. Dynamic Craniotomy With Khanna NuCrani Plates as an Alternative to Craniotomy With Fixed Plates in Traumatic Brain Injury. Neurosurgery ():10.1227/neu.0000000000003244, November 4, 2024. PMID: 39495022. DOI: 10.1227/neu.0000000000003244

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January 2023: Dynamic craniotomy with Khanna NuCrani plates reporting early clinical experience published in peer reviewed Operative Neurosurgery. 

Khanna R, Munz M, Baxter S, Han P. Dynamic Craniotomy With NuCrani Reversibly Expandable Cranial Bone Flap Fixation Plates: A Technical Report. Oper Neurosurg (Hagerstown). 2023 Jan 1;24(1):94-102. doi: 10.1227/ons.0000000000000438. Epub 2022 Oct 18. PMID: 36519883. https://doi.org/10.1227/ons.0000000000000438

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March 2020: US FDA Clearance of NeuroVention Cranial Fixation System with indications of use: 

The NeuroVention Cranial Fixation System is intended for use as a burr hole cover and/or skull bone fixation following craniotomy, cranioplasty, or craniectomy surgery.

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January 2019: Dynamic craniotomy with Khanna NuCrani plates cadaver and biomechanical study published in peer reviewed Journal of Neurosurgery.

Khanna R, Ferrara L, Khanna S. Biomechanics of a novel reversibly expandable dynamic craniotomy bone flap fixation plate. J Neurosurg. 2019 Jan 4;132(2):560-567. doi: 10.3171/2018.8.JNS172614. PMID: 30611148. https://doi.org/10.3171/2018.8.jns172614

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July 2017: Dynamic decompressive craniotomy study with the reversibly expandable plate published in peer reviewed Central European Journal of Neurological surgery

Khanna R. Dynamic Decompressive Craniotomy with a Novel Reversibly Expandable Plate. J Neurol Surg A Cent Eur Neurosurg. 2017 Jul;78(4):386-389. doi: 10.1055/s-0036-1594013. Epub 2016 Nov 30. PMID: 27903020. https://doi.org/10.1055/s-0036-1594013

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September 2016: Dynamic Telescopic Study featured on cover page of Journal of Neurosurgery

https://thejns.org/view/journals/j-neurosurg/125/3/j-neurosurg.125.issue-3.xml

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December 2015: Dynamic Telescopic Study published in peer reviewed Journal of Neurosurgery illustrating the technique and efficacy.

Khanna R, Ferrara L. Dynamic telescopic craniotomy: a cadaveric study of a novel device and technique. J Neurosurg. 2016 Sep;125(3):674-82. doi: 10.3171/2015.6.JNS15706. Epub 2015 Dec 11. PMID: 26654180. https://doi.org/10.3171/2015.6.jns15706

 

 

 

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